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2024

INTEGRATED PHENOTYPIC AND ACTIVITY-BASED PROFILING OF ELECTROPHILIC FRAGMENTS REVEALS NEW TARGETS FOR ANTIBIOTICS DEVELOPMENT




Jin, Y., Jana, S., Abbasov, M. E.,* Lin, H.*
BioRvix 2024 DOI: 10.1101/2024.01.22.576576.



Activity-Based Acylome Profiling with N-(Cyanomethyl)-N-(phenylsulfonyl)amides for Targeted Lysine Acylation and Post-Translational Control of Protein Function in Cells




Ryan, E. M., Norinskiy, M. A., Bracken, A. K., Lueders, E. E., Chen, X., Fu, Q., Anderson, E. T., Zhang, S., Abbasov, M. E.*
J. Am. Chem. Soc. 2024, 146, 40, 27622-27643.



Biomimetic synthesis and chemical proteomics reveal the mechanism of action and functional targets of phloroglucinol meroterpenoids




Bracken, A. K., Gekko, C. E., Suss, N. O., Lueders, E. E., Cui, Q., Fu, Q., Anderson, E. T., Zhang, S., Abbasov, M. E.*
J. Am. Chem. Soc. 2024, 146, 4, 2524–2548.


2021

A proteome-wide atlas of lysine-reactive chemistry


Abbasov, M. E., Kavanagh, M., Ichu, T.-A., Lazear, M. R., Tao, Y., Crowley, V. M., am Ende, C. W., Hacker, S. M., Ho, J., Dix, M. M., Suciu, R., Hayward, M. M., Kiessling, L. L., Cravatt, B. F.
Nat. Chem. 2021, 13, 1081–1092.


2020

ENANTIOSELECTIVE, ORGANOCATALYTIC STRATEGY FOR THE OXAZOLOMYCIN CORE: FORMAL SYNTHESIS OF (+)- NEOOXAZOLOMYCIN


Chaheine, C. M., Gladen, P. T., Abbasov, M. E., Romo, D.
Org. Lett. 2020, 22, 9282–9286.

2019

Simplified immunosuppressive and neuroprotective agents based on gracilin A


Abbasov, M. E., Alvariño, R.; Chaheine, C. M.; Alonso, E.; Sánchez, J. A.; Conner, M. L.; Alfonso, A.; Jaspars, M.; Botana, L. M.; Romo, D.
Nat. Chem. 2019, 11, 342–350.



Gracilin A derivatives target early events in Alzheimer’s disease: effects on neuroinflammation and oxidative stress


Alvariño, R., Alonso, E., Abbasov, M. E., Chaheine, C. M., Conner, M. L., Romo, D., Alfonso, A., Botana, L. M.
ACS Chem. Neurosci. 2019, 10, 4102–4111.

2017

Enantioselective Diels-Alder-lactamization organocascades employing a furan-based diene


Abbasov, M. E., Hudson, B. M., Tantillo, D. J., Romo, D.
Org. Biomol. Chem. 2017, 15, 3179–3183.



Stereodivergent, Diels-Alder-initiated organocascades employing α,β-unsaturated acylammonium salts: scope, mechanism, and application


Abbasov, M. E., Hudson, B. M., Tantillo, D. J., Romo, D.
Chem. Sci. 2017, 8, 1511–1524.

2014

Acylammonium salts as dienophiles in Diels-Alder/lactonization organocascades


Abbasov, M. E., Hudson, B. M., Tantillo, D. J., Romo, D.
J. Am. Chem. Soc. 2014, 136, 4492–4495.



The ever-expanding role of asymmetric covalent organocatalysis in scalable, natural product synthesis


Abbasov, M. E., Romo, D.
Nat. Prod. Rep. 2014, 31, 1318–1327.

2012

Effects of carbon nanotubes on electro-optical properties of dye-doped nematic liquid crystal


Abbasov, M. E., Carlisle, G. O.
J. Mater. Sci.: Mater. Electron. 2012, 23, 712–717.

2010

Hybrid carbon nanotube and dye-doped liquid crystal material for holographic imaging


Abbasov, M. E., Ghosh, S., Quach, A., Carlisle, G. O.
J. Mater. Sci.: Mater. Electron. 2010, 21, 854–859.



Optical properties of permanent gratings in liquid crystal doped with dye and carbon nanotube


Suleiman, Y. S., Ghosh, S., Abbasov, M. E., Carlisle, G. O.
J. Mater. Sci.: Mater. Electron. 2008, 19, 662–668.


2024

CHEMICAL ACYLATING AGENTS AND CHEMOPROTEOMIC METHODS FOR POSTTRANSLATIONAL MODULATION OF PROTEIN FUNCTION IN LIVE CELLS


Ryan, E. M., Norinskiy, M. A., Abbasov, M. E.
Provisional patent application filed on May 3, 2024. Docket No. 11135-01-US.


2023

PHLOROGLUCINOL MEROTERPENOIDS AS LYSINE-TARGETING CHEMICAL PROBES FOR MODULATING MITOPHAGY AND DEGRADING BRCA1-MUTANT ONCOPROTEIN


Bracken, A. K., Gekko, C. E., Abbasov, M. E.
Provisional patent application filed on September 27, 2023. Docket No. 10898-01-US. App. No. 63/540, 783.


2018

Gracilin A and congeners as immunosuppressive and neuroprotective agents


Abbasov, M. E., Alvariño, R., Alonso, E., Sánchez, J. A., Alfonso, A., Botana, L. M., Romo, D.
U.S. Application No. 62/638,856 (WO/2019/173382). March 5, 2018.